Dutasteride counterproductive on DHT based compounds?

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asgarali • Sun, Mar 22nd, ’15 23:41 • 2 replies, 178 views
So we know dutasteride and other DHT inhibitors help us to mitigate DHT conversion on cycle.

However I have a concern about its use on a cycle that is based on DHT compounds. I’m about to run a cycle of Test E, Masteron and Primobolan, mast and primo both of which are DHT based compounds.

Yes dutasteride will prevent test formation to DHT, but at the same time would it have a counter-productive effect on the Masteron and Primobolan as they are both DHTs ?

Im thinking it could be either of the following:

1) Dutasteride simply prevents the conversion but does not affect the existing DHT so might it leave the masteron and primo to do its thing?


2) Dutasteride prevents conversion AND also eliminates/mitigates already existing DHTs. If this is the way it works I believe it may send my Masteron and Primobolan down the drain.

What do you guys think?


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quick89 1 year ago
I’m pretty sure primo isn’t a DHT, and is instead a DHB (dihydroboldenone) as primo and DHB only vary by a methyl group.

And in my opinion drugs that stop 5ar simply do that, I don’t think it would inhibit the efficacy of the primo or the mast. Just an opinion and I could easily be wrong though.

GearHead 1 year ago @quick89
Dutasteride will not reduce the effectiveness of DHT derived compounds nor will it have any effect on DHT or hairloss and, yes, primo is derived from boldenone as you say.

DHT blockers effect results?
JSS • Thu, May 10th, ’12 02:51 • 7 replies, 1446 views
Any one here used propecia and juice at the same time and still get good results? i have heard that dht blocker is good and bad for muscle growth.


msus504 4 years ago
Treatment with a 5-alpha reductase inhibitor did not adversely affect fat-free mass in healthy men given varying doses of testosterone, a randomized trial showed.

Mean fat-free mass increased by 0.6 to 7.1 kg over 20 weeks in men taking dutasteride (Avodart) and different doses of testosterone enanthate. Men treated with placebo and testosterone gained an average of 0.8 to 8.1 kg in fat-free mass.

Muscle strength, sexual function, and prostate volume also did not differ significantly between treatment groups, as reported in the March 7 issue of the Journal of the America Medical Association.

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“The finding that 5α-reduction of testosterone to DHT [dihydrotestosterone] is not obligatory for mediating its effects on outcomes that were studied in this trial has implications for therapeutic applications of androgens and 5α-reductase inhibitors,” Shalender Bhasin, MD, of Boston University, and co-authors wrote. “These findings bode well for the safety of 5α-reductase inhibitors with respect to their effects on muscle.”

Hope this helps a little…..

msus504 4 years ago @msus504
There is more so PM if you need to….

ikemay 4 years ago
i was taking it before for about a month before i heard of sexual sides, screw that, dropped it real quick.

JSS 4 years ago
well i have used it since i was 17 and i am now nearly 22 and i have had pretty good natural muscle growth and no bad side effects

dbolz 4 years ago @JSS
You are too young for any side effects and also not everyone will become impotent from it. If you do run in any problems though later in life it will probably be due to that. Also you dont know what your natural muscle growth would have been without it. You are in the golden age at the momment so enjoy. After 25 you will have to rethink your tactics. When RU58841 is going to come out there wont be any need for propecia anyway
dbolz 4 years ago
Like any ancillary it will affect your results, dht is much more anabolic than test it self so basically you are missing on its effects the more you suppress it. Also you will be converting a lot more estrogen while using it so expect more bloat even if you are taking your AI’s. I wouldnt use propecia due to the unwanted sexual side effects it could have to ones libido and sterility. Before you get on propecia make sure you research long and hard on the substance. There are horror stories online people became infertile and impotent after propecia and seizing use of the drug didnt help them either. Thats one medicine you shouldnt take unless you really have too. RU58841 sounds promising but it has not been approved yet. You can still source it though if you are the experimental type. I suggest you have a look at that.

test undecanoate

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